San Francisco 49ers quarterback Brock Purdy is still making quite an impact in the state of Iowa despite being three years removed from his playing days for the Cyclones. Purdy and the Niners will play in one of three games that will air on Fox during the later slate of games at 1 p.

San Francisco 49ers quarterback Brock Purdy isn't letting early-season injuries shake his confidence. Although he has been without reigning NFL Offensive Player of the Year Christian McCaffrey for the first two games—McCaffrey will miss at least the next three with Achilles tendinitis—Purdy remains optimistic.

In Purdy's last seven starts, he has won four games, lost three, thrown six touchdown passes and six interceptions, fumbled once and posted a passer rating of 87. That's about as average as it gets. And he's playing on the best team in football.

Newsweek's NFL betting expert provides the best NFL Week 3 underdog picks, including the Vikings over the Texans and the Chargers over the Steelers.

The San Francisco 49ers (1-1) are 6.5-point favorites when they visit the Los Angeles Rams (0-2) in an NFC West matchup on Sunday, September 22, 2024 at SoFi Stadium.NFL odds courtesy of BetMGM