In the lawsuit filed early Friday in federal court in Boston, the Ivy League school called out the government’s ban as a violation of the Constitution and warned that it would have an “immediate and devastating effect for Harvard and more than 7,000 visa holders.”

The Administration’s move is the latest escalation in its attack on elite universities across the U.S., with heavy penalties levied on Harvard, including a threat to revoke the university’s tax-exempt status. Those penalties have only grown more severe as Harvard has refused to capitulate to the Administration’s demands.

The president’s fight threatens to leave the school a different place even if it ultimately wins its lawsuits.