At least 21 people were killed overnight in Kentucky and Missouri when a volatile weather system spawned tornadoes as it ripped across a large swath of the U.S. Midwest and Great Lakes, officials said on Saturday.

Tornadoes and sever storms hit several parts of the US on Friday, leaving at least 23 dead and thousands of buildings damaged.

A tornado outbreak swept across the Ohio Valley Friday night, leaving at least 27 dead and rescue crews frantically searching neighborhoods left in ruins for any other survivors. So far, at least 14 people have died in Kentucky,